The Inserm UMRS-1116 Team 2 and the center of clinical investigation pluri-thematic of Nancy (CIC-1433) are world-class environment for basic, translational and clinical research. Our interest covers a broad spectrum of cardiovascular diseases by spanning molecular and cellular biology, biomarkers of physiologic and pathophysiologic ageing, biomarkers of the response to anti-fibrotic drug. The objective of our team is to develop basic research and to use the knowledge generated to improve diagnosis, prognosis, therapy for HF within the continuum between fundamental knowledge and patient care.
The successful post-doctoral fellow with a PhD in biochemistry or molecular biology, will study the genetic determinism of Heart Failure (HF) and validate the predictive value of biomarkers in foreseeing the progression of HF as well as the response to an antifibrotic drug. He/she will focus on refining the pharmaco-phenomic analysis already performed that previously identified in a murine model several signaling pathways reflecting the impact of both obesity and chronic anti-fibrotic treatment on the degree of HF development. The post-doctoral fellow will concentrate his/her efforts in validating at the protein level the beneficial signaling pathways modulated by the treatment in an organ no- or specific manner (heart and kidney).
To achieve these objectives, various approaches will be combined. This requires skills in biochemistry, molecular biology, immuno-histochemistry/in situ hybridization and strong knowledge in cardio-renal diseases. An important aspect of the post-doctoral project will be translational. Based on the experimental findings he/she will participate to the validation of the identified biomarkers in clinical trial data sets. Knowledge in biostatistics will be a plus.
Perfectly at ease in a multidisciplinary environment, the post-holder should be proactive, independent, have excellent organization and communication skills. Excellent English level is mandatory.
A contract of 1-year (possibly extended) is immediately available (could start later if current position finalization is pending). Motivated candidate should send an application letter, CV and 2 reference names to Dr A. Pizard (firstname.lastname@example.org) before the May 15th 2016.